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br Materials and Methods br
2018-11-09

Materials and Methods Results Discussion TBI-based conditioning regimens have not prevented leukemic relapses post-HSCT (Uckun et al., 1993a; Pulsipher et al., 2009; Balduzzi et al., 2014; Bar et al., 2014; Bachanova et al., 2012). Therefore, the identification of new drugs that can help ov
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The following are the supplementary data related
2018-11-09

The following are the supplementary data related to this article. Author Contributions Competing Financial Interests Acknowledgments We thank Mr. K. Howell and K. Johnson for help with animals, Mr. L. Charalambous for generating kymographs, and Mr. T. Christensen for help with EM. This res
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bms-690514 These data do not provide
2018-11-09

These data do not provide evidence that the MMP production from macrophages is directly regulated by CBP/β-catenin and that the produced MMPs are involved in fibrosis resolution in our model. The gating strategy for macrophages in analysis of IHL does not exclude monocytes. Moreover, the mechanism b
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The first finding is that even in
2018-11-09

The first finding is that even in the era of highly effective TB chemotherapy (namely the regimen used in the IMPI trial), the mortality of TB pericarditis is still high, with an overall mortality rate of 1.43 per 100person-months in a median follow-up of 11.97months. The most plausible explanation
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In the present study we introduce
2018-11-08

In the present study, we introduce a novel cell surface protein, CD98, that is specifically expressed on the cells of the basal layer and, in addition, remains stably expressed after a multitude of proteolytic treatments. We show that purified CD98high cells are able to induce tumor growth upon seri
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Selecting suitable microcarriers for cell propagation
2018-11-08

Selecting suitable microcarriers for cell propagation is usually the first step for the development of any microcarrier based process including hESC culture. Different commercially available microcarriers were used by Phillips et al. (2008), Oh et al. (2009), Nie et al. (2009), and Lock and Tzanakak
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br Materials and methods br Results br Discussion Attempts t
2018-11-08

Materials and methods Results Discussion Attempts to identify a resident adult stem cell in the kidney have led to the identification of CD133+/CD24+ cells in the Bowman\'s capsule (Sagrinati et al., 2006) or CD133+ cells in the renal cortex (Bussolati et al., 2005) and in the renal inner m
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br Materials and methods br Results br
2018-11-08

Materials and methods Results Discussion Recent neurogenesis studies and the discovery of multipotent neural stem norepinephrine bitartrate derived from the adult mammalian CNS, including that of humans, have had a considerable influence on potential treatments for neural injury (Gross, 20
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Taken together we conclude that Lats may regulate adult card
2018-11-08

Taken together, we conclude that Lats may regulate adult cardiomyocyte hypertrophy independent of Yap or Tead1. Rather than controlling cardiac hypertrophic growth, the canonical Hippo/Yap pathway is crucial for regulation of cardiomyocyte survival in the adult heart. This parallels the findings in
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br Materials and methods br Results and discussion
2018-11-08

Materials and methods Results and discussion Acknowledgments Introduction Reprogramming rejuvenates aged somatic cells back into the pluripotent state (Takahashi et al., 2007; Takahashi and Yamanaka, 2006). The developmental plasticity of induced pluripotent stem cells (iPSC) demonstrate
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br Materials and methods br Statistical analysis Data are pr
2018-11-08

Materials and methods Statistical analysis Data are presented as mean±SEM. Differences between groups were detected for statistical significance using the unpaired Student\'s t-test. P Results Discussion We have previously postulated that Hopx might label NSCs in the dentate gyrus based u
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br Materials and methods br Acknowledgments We
2018-11-08

Materials and methods Acknowledgments We would like to thank Dr. Keisuke Okita and Prof. Shinya Yamanaka for providing the plasmids for reprogramming. We thank Bente Smith Thorup for excellent technical assistance in the cell culture. We thank Mehri Mirrajei for cytogenetic technical assistanc
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Although there is strong clinical support for
2018-11-08

Although there is strong clinical support for developing cellular therapies, and the use of such therapies is already reaching clinical translation (Götherström et al., 2014), ethical issues associated with the collection and use of fetal tissue for research and therapy still remain. Concerned polit
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An important step towards further ACC CSC characterization i
2018-11-08

An important step towards further ACC-CSC characterization is identification of CD markers which, in combination with CD133, may be used for FACS sorting and multiplexed CyTOF analysis of ACC-heterogeneity and their signaling states. Such studies may significantly advance understanding of ACC-CSC ro
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beta-lactamase br Materials and methods br Results
2018-11-08

Materials and methods Results Discussion NPY is one of the most common neuropeptides in mammals, and it is abundant in the central and peripheral nervous system. Recent studies have indicated that the neuropeptides SP and NPY can regulate many biological activities in BMSCs and MC3T3 beta-l
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