• br Acknowledgments The authors thank Elisabete Lepera and Ro

  2020-05-22

  

  Acknowledgments The authors thank Elisabete Lepera and Rosana Silva for technical support. The study was supported by FAPESP, CNPq and PADC/FCF-UNESP. T.T. Miguel was the recipient of a FAPESP (Proc. 05/05171-1) and R.L. Nunes-de-Souza of a CNPq (Proc. 303580/2009-7) fellowship. Introduction

• RNA sequencing RNA seq is a particularly

  2020-05-21

  

  RNA-sequencing (RNA-seq) is a particularly effective technology for gene discovery in a given process, especially in non-model species for which reference genome sequences are not available. Although the major application of RNA-seq analyses is the identification of differentially expressed genes (

• Data from our in vitro studies using BEAS B

  2020-05-21

  

  Data from our in vitro studies using BEAS-2B cells showed a biphasic response of cells to NNK. The initial phase of decrease in CRM1 expression in NNK-exposed cells was observed in our previous study. In this study, we further showed that p-p53 (Thr55) expression was also decreased during this initi

• In this study new and more extended tables of parameters

  2020-05-21

  

  In this study, new and more extended tables of parameters were estimated for pure fluids and binary mixtures that are relevant to biodiesel systems. Also, calculations for glyceride systems will be shown, which is a topic not investigated before with the CPA model. As before [21], [22], [23], [24],

• br Conclusion br Acknowledgement The project was supported b

  2020-05-21

  

  Conclusion Acknowledgement The project was supported by National Natural Science Foundation of China, China (No. 31872535); Natural Science Foundation of Shandong Province, China (ZR2018MC027, ZR2016CQ29); and Funds of Shandong \"Double Tops\" Program, China. Introduction High-altitude hyp

• Drug resistance to both pathogens and cancer has been

  2020-05-21

  

  Drug resistance to both pathogens and cancer has been a big hindrance in healthcare. Integrated research undertakings are being pursued to find the exact causes of the lack of response towards drugs. Surprisingly, host pumps are the key factors in failure of most drugs. The pumps either do not allow

• While we previously demonstrated that TraG is inhibited by s

  2020-05-21

  

  While we previously demonstrated that TraG is inhibited by specific transglycosylase inhibitors and that enzymatic activity is strongly reduced upon mutation of the potential catalytic core (Arends et al., 2013), the enzymatic mechanism of both domains was not assigned. Here, by mass spectrometry an

• The cytoplasmic domain of classical cadherins is highly

  2020-05-21

  

  The cytoplasmic domain of classical cadherins is highly conserved and can interact with different cytosolic proteins. Typically this domain is associated with catenin family members, including p120 catenin, β-catenin, and α-catenin, which form a cadherin-catenin complex (Fig. 1). The catenin family

• To determine whether the same concentration of humic acid ca

  2020-05-21

  

  To determine whether the same concentration of humic 2536 synthesis causes changes in PCR efficiency, we performed another experiment in which the humic acid was added to the PCR mix after bisulfite conversion. All samples that were amplified in the presence of humic acid (thick lines) show a decre

• A range of inhibitors were therefore synthesized containing

  2020-05-21

  

  A range of inhibitors were therefore synthesized containing either carboxylic bcr-abl tyrosine kinase inhibitors or ester functionality at the ‘tail’ group as well as variations in the ‘head.’ These were assayed in vitro using the DCIP assay for binding affinity against and human DHODH at 50μM, re

• Cell lines which possess microglial or neuronal properties a

  2020-05-21

  

  Cell lines which possess microglial or neuronal properties are uncomplicated and convenient in vitro models for studying 5-fluorocytosine injury at the cellular and molecular levels. Microglial BV-2 cells are derived from the immortalized mouse microglia and exhibit many of the morphological, pheno

• tazemetostat br Conclusions The present study demonstrated

  2020-05-21

  

  Conclusions The present study demonstrated that CuE possesses strong hepatotoxicity. CuE is not only a mechanism-based inhibitor of human CYP3A4, but also inhibits P-gp activity in vitro. In whole animal studies, CuE induces CYP3A and P-gp after a long-term treatment but inhibits the activities o

• We then undertook computational studies that

  2020-05-20

  

  We then undertook computational studies that suggest the cyanobacterial ALDH (and planctomyces ALDH) represent the evolutionary ancestor of human and other eukaryotic ALDH1/2 given that cfALDH contains signature residues matching both the human proteins throughout the surface of the protein and the

• In conclusion our results demonstrated that TGF

  2020-05-20

  

  In conclusion, our results demonstrated that TGF-β1 promotes linear invadosome formation in hepatocellular carcinoma cells, through the regulation of collagen I, its receptor and its cross-linker (Fig. 6). The key role of TGF-β1 in HCC development allow us to suggest that linear invadosomes and thei

• The presence of H PPases in parasitic protists raises

  2020-05-20

  

  The presence of H+-PPases in parasitic protists raises the question of the physiological role of these proteins. So far, they had been extensively characterized mainly in higher plants, and some prokaryotes [1], [2], [3], [4], [5], [6], [7], [16], [20]. A common feature to all these organisms is tha

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