• Numerous clinical trials phase II and phase III have been

  2019-04-23

  

  Numerous clinical trials (phase II and phase III) have been then designed to evaluate the efficacy of denosumab in oncology mainly in breast and prostate bone metastases (Table 1). These studies revealed that denosumab reduced significantly bone turnover markers similarly to osteoporotic patients. M

• A type saddle back type or type ST segment elevation

  2019-04-23

  

  A type 2 (“saddle-back type”) or type 3 ST-segment elevation cannot substitute for a type 1, unless converted to type 1 with fever or sodium drug challenge. A drug challenge–induced type 1 can be used to diagnose BrS only if accompanied by 1 of the criteria specified above. Type 2 is characterized b

• Yang et al reported PSA

  2019-04-23

  

  Yang et al. reported PSA triggered TRUSP biopsy in Korea. This study included 75 patients younger than 40 years of age, with PSA > 4.0 ng/mL; the PCa detection rate was 1.3% in the Korean study. In comparison, there were substantially more abnormal DRE findings and significant LUTS findings in our s

• I received a grant from

  2019-04-22

  

  I received a grant from The Kendeda Fund to write and promote my book, , on which this comment is based. I thank Richard King (Chatham House, London, UK) for data assistance, Christian Guthier (All is Possible, Oxford, UK) for graphic design, and Sarah Cornell (Stockholm Resilience Centre, Stockholm

• The study reported high rates of

  2019-04-22

  

  The study reported high rates of antimicrobial resistance and also reminds us of the paucity of new drugs to treat such infections, especially in neonates, as well as the paucity of data on antimicrobial pharmacokinetics in this population. Observational and interventional multicentre studies are ne

• Countdown to concluded its tasks after the

  2019-04-22

  

  Countdown to 2015 concluded its tasks after the launch of its seventh global report at the Maternal Newborn Health conference in Mexico City, October, 2015. It is now relaunched as Countdown to 2030 (CD2030), retaining and enhancing the successful multi-institutional network with over a decade of he

• Regarding the pathophysiology of HF with

  2019-04-22

  

  Regarding the pathophysiology of HF with preserved LVEF, AF is one of the most important precipitating factors related to diastolic dysfunction [22,23]. AF might have important roles in the pathogenesis of HF with preserved EF in association with diastolic HF. Compared with JCARE-CARD, which include

• Our investigation suggests that cardiac pacing improves not

  2019-04-22

  

  Our investigation suggests that cardiac pacing improves not only CSA but also OSA. The mechanism by which SDB is improved is unclear. CSA might be improved by reduction of periodic variations in heart rate, which are increased by meclofenoxate and may result in part from changes in autonomic tone.

• Another mechanism is that J waves represent a

  2019-04-22

  

  Another mechanism is that J waves represent a repolarization abnormality where J waves are created by the transmural voltage gradient [16]. During myocardial ischemia, the membrane ionic currents are known to be augmented, in turn augmenting the transient outward current (Ito). Augmented Ito would r

• In patients with typical atrial

  2019-04-22

  

  In patients with typical atrial flutter circulating around the tricuspid valve, the verification of a bidirectional conduction block is recommended for cavotricuspid isthmus (CTI) ablation, because a unidirectional conduction block at the CTI has been previously reported to cause recurrence of atria

• Based on the methodology used in

  2019-04-22

  

  Based on the methodology used in previous studies, the EGM source for the Wavelet algorithm has been nominally programmed as the Can-RV coil EGM [13]. As the nominal EGM source includes the generator, myopotentials induced due to body motion or other muscle activity are likely to influence the arrh

• br Results In all patients no abnormalities were

  2019-04-22

  

  Results In all patients, no abnormalities were found in the left axillary, left subclavian, or left brachiocephalic veins, such as blood vessel occlusion or stenosis. The procedure time was 138.6±41.8min in the conventional puncture group (Group A) and was 109.8±23.2min in the catheter-guided pun

• In this study we applied

  2019-04-22

  

  In this study, we applied a more general approach along these lines, which has previously been used only in few reports in the literature [8]. Based on a prospective BC database including all newly diagnosed BC cases at a large Swiss breast center over a 20-year period, we aimed to give a comprehens

• mitoxantrone Conflicting findings have been reported on the

  2019-04-22

  

  Conflicting findings have been reported on the survival and function recovery between treatments of LSS and amputation in patients with osteosarcoma. Toward this end, a meta-analysis of published clinical trials was performed to compare the clinical efficacy of LSS and amputation treatments in terms

• br Conflict of interest br

  2019-04-22

  

  Conflict of interest Acknowledgments Background of basic genetics The human genome contains approximately 3 billion nucleotide Madecassoside pairs contained in 23 chromosome pairs. Each chromosome contains hundreds to thousands of genes and the estimated 30,000 genes in the human genome ex

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